Treatments for CRPS type 1 supported by evidence of efficacy and little
likelihood for harm are: topical DMSO cream, IV bisphosphonates, and
limited courses of oral corticosteroids. Despite some contradictory
evidence, physical therapy and calcitonin (intranasal or intramuscular)
are likely to benefit patients with CRPS type 1.
Due to modest benefits and the invasiveness of the therapies, epidural
clonidine injection, intravenous regional sympathetic block with bretylium
and spinal cord stimulation should be offered only after careful counseling.
Therapies to avoid due to lack of efficacy, lack of evidence, or a
high likelihood of adverse outcomes are IV regional sympathetic blocks
with anything but bretylium, sympathetic ganglion blocks with local
anesthetics, systemic IV sympathetic inhibition, acupuncture, and sympathectomy.
Quisel A, Gill JM, Witherell P. J Fam Pract. 2005 Jul;54(7):599-603.
PMID 16009087
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16009087&query_hl=31
Credit: PubMed, developed by the National Center for Biotechnology Information
(NCBI) at the National
Library of Medicine (NLM).
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