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Fatigue is more frequent than previously thought in immune-mediated
polyneuropathies. However, fatigue has not been reported as the main cause
of referral in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
patients. Between January 2001 and December 2003, these researchers investigated
11 patients referred for fatigue, for which we established a final diagnosis
of CIDP. All patients had at least two clinical examinations including assessment
of the fatigue severity scale (FSS) and one electrophysiological and laboratory
work up. Additionally, 10 of the 11 patients had a nerve biopsy. All were
male; mean age at onset was 53 +/- 11 years. Main cause of referral was fatigue
in all patients. Other symptoms included cramps (one case), distal paresthesias
(six cases), limb pain (seven cases), and vasomotor disturbances (one case).
This study shows that fatigue is a possible cause of referral for patients
with CIDP and, like previous reports, emphasizes the lack of sensitivity of
widely accepted electrophysiological criteria of CIDP. Long-term follow up
of these patients is warranted to determine the prognosis of these minimal
forms of CIDP and establish the best therapeutic strategy in such cases. Boukhris
S, Magy L, Gallouedec G, Khalil M, Couratier P, Gil J, Vallat JM. Adapted
from J Peripher Nerv Syst. 2005 Sep;10(3):329-37.
Read more: PMID 16221292
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16221292&query_hl=10
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